No.

게재년도

논문명

저자명

학술지명

Vol.(No.)

161

2017.1

The anti-ALS drug riluzole attenuates pericyte loss in the diabetic retinopathy of streptozotocin-treated mice.

Choi JA, Chung YR, Byun HR, Park H, Koh JY, Yoon YH.

Toxicol Appl Pharmacol

8;315:80-89

160

2016.11

Efficacy and safety of aflibercept in in vitro and in vivo models of retinoblastoma.

Kim DY, Choi JA, Koh JY, Yoon YH

J Exp Clin Cancer Res

4;35(1):171

159

2016.8

A novel mechanism for the pyruvate protection against zinc-induced cytotoxicity: mediation by the chelating effect of citrate and isocitrate.

Sul JW, Kim TY, Yoo HJ, Kim J, Suh YA, Hwang JJ, Koh JY.

Arch Pharm Res

39(8):1151-9

158

2016.6

Autism phenotypes in ZnT3 null mice: Involvement of zinc dyshomeostasis, MMP-9 activation and BDNF upregulation

Yoo MH, Kim TY, Yoon YH, Koh JY

Sci Rep

29;6:28548

157

2016.6

Inhibition of EHMT2/G9a epigenetically increases the transcription of Beclin-1 via an increase in ROS and activation of NF-κB.

Park SE, Yi HJ, Suh N, Park YY, Koh JY, Jeong SY, Cho DH, Kim CS, Hwang JJ.

Oncotarget

28;7(26):39796-39808

156

2016.2

AMP-activated protein kinase contributes to zinc-induced neuronal death via activation by LKB1 and induction of Bim in mouse cortical cultures.

Eom JW, Lee JM, Koh JY, Kim YH.

Mol Brain

9;9:14

155

2015.12

Heterogeneous nuclear ribonucleoprotein A1 post-transcriptionally regulates Drp1 expression in neuroblastoma cells.

Park SJ, Lee H, Jo DS, Jo YK, Shin JH, Kim HB, Seo HM, Rubinsztein DC, Koh JY, Lee EK, Cho DH

Biochim Biophys Acta

1849(12):1423-31

154

2015.12

Pyruvate and cilostazol protect cultured rat cortical pericytes against tissue plasminogen activator (tPA)-induced cell death.

Kim HN, Kim TY, Yoon YH, Koh JY

Brain Res

2;1628(Pt B):317-26

153

2015.12

The zinc ionophore clioquinol reverses autophagy arrest in chloroquine-treated ARPE-19 cells and in APP/mutant presenilin-1-transfected Chinese hamster ovary cells

Seo BR, Lee SJ, Cho KS, Yoon YH, Koh JY

Neurobiol Aging

36(12):3228-38

152

2015.12

Metallothionein-3 modulates the amyloid β endocytosis of astrocytes through its effects on actin polymerization.

Lee SJ, Seo BR, Koh JY

Mol Brain

4;8(1):84

151

2015.9

Angiopoietin-1 blocks neurotoxic zinc entry into cortical cells via PIP2 hydrolysis-mediated ion channel inhibition.

Lim JS, Koh GY, Koh JY

Neurobiol Dis

81:203-13

150

2015.7

Developmental endothelial locus-1 is a homeostatic factor in the central nervous system limiting neuroinflammation and demyelination

Choi EY, Lim JH, Neuwirth A, Economopoulou M, Chatzigeorgiou A, Chung KJ, Bittner S, Lee SH, Langer H, Samus M, Kim H, Cho GS, Ziemssen T, Bdeir K, Chavakis E, Koh JY, Boon L, Hosur K, Bornstein SR, Meuth SG, Hajishengallis G, Chavakis T

Mol Psychiatry

20(7):880-8

149

2015.7

Amyloid Beta-Weighted Cortical Thickness: A New Imaging Biomarker in Alzheimer`s Disease.

Kim CM, Hwang J, Lee JM, Roh JH, Lee JH, Koh JY; Alzheimer’s Disease Neuroimaging Initiative (ADNI).

Curr Alzheimer Res

12(6):563-71.

148

2015.5

Trans-synaptic zinc mobilization improves social interaction in two mouse models of autism through NMDAR activation

Lee EJ, Lee H, Huang TN, Chung C, Shin W, Kim K, Koh JY, Hsueh YP, Kim E

Nat Commun

18;6:7168

147

2015.3

Anti-angiogenic effect of metformin in mouse oxygen-induced retinopathy is mediated by reducing levels of the vascular endothelial growth factor receptor flk-1.

Joe SG, Yoon YH, Choi JA, Koh JY

PLoS One

18;10(3):e0119708

146

2015.2

Raloxifene Induces Autophagy-Dependent Cell Death in Breast Cancer Cells via the Activation of AMP-Activated Protein Kinase

Kim DE, Kim Y, Cho DH, Jeong SY, Kim SB, Suh N, Lee JS, Choi EK, Koh JY, Hwang JJ, Kim CS

Mol Cells

38(2):138-44

145

2015.1

Indomethacin preconditioning induces ischemic tolerance by modifying zinc availability in the brain

Lee JY, Oh SB, Hwang JJ, Suh N, Jo DG, Kim JS, Koh JY.

Neurobiol Dis

81:186-95

144

2014.11

Suppression of Cpn10 increases mitochondrial fission and dysfunction in neuroblastoma cells.

Park SJ, Jo DS, Shin JH, Kim ES, Jo YK, Choi ES, Seo HM, Kim SH, Hwang JJ, Jo DG, Koh JY, Cho DH.

PLoS One

12;9(11):e112130

143

2014.9

Abnormalities in the zinc-metalloprotease-BDNF axis may contribute to megalencephaly and cortical hyperconnectivity in young autism spectrum disorder patients.

Koh JY, Lim JS, Byun HR, Yoo MH.

Mol Brain

3;7:64

142

2014.9

The role of metallothionein-3 in streptozotocin-induced beta-islet cell death and diabetes in mice

Byun HR, Choi JA, Koh JY.

Metallomics.

6(9):1748-57

141

2014.4

Tissue plasminogen activator arrests Alzheimer’s disease pathogenesis

Oh SB, Byun CJ, Yun JH, Jo DG, Carmeliet P, Koh JY, Lee JY.

NEUROBIOLOGY OF AGING

35(3):511-9

140

2014.4

The role of reciprocal activation of cAbl and Mst1 in the Oxidative death of cultured astrocytes.

Lee SJ, Seo BR, Choi EJ, Koh JY.

Glia

62(4):639-48

139

2014.4

The role of reciprocal activation of cAbl and Mst1 in the Oxidative death of cultured astrocytes.

Lee SJ, Seo BR, Choi EJ, Koh JY.

Glia

62(4):639-48

138

2014.1

Down-regulation of Mortalin Exacerbates A -mediated Mitochondrial Fragmentation and Dysfunction

Park SJ1, Shin JH, Jeong JI, Song JH, Jo YK, Kim ES, Lee EH, Hwang JJ, Lee EK, Chung SJ, Koh JY, Jo DG, Cho DH.

JOURNAL OF BIOLOGICAL CHEMISTRY

24;289(4):2195-204.

137

2013.12

BIX-01294 induces autophagy-associated cell death via EHMT2/G9a dysfunction and intracellular reactive oxygen species production

Kim Y1, Kim YS, Kim DE, Lee JS, Song JH, Kim HG, Cho DH, Jeong SY, Jin DH, Jang SJ, Seol HS, Suh YA, Lee SJ, Kim CS, Koh JY, Hwang JJ.

Autophagy

9(12):2126-39

136

2013.12

Angiotensin II potentiates zinc-induced cortical neuronal death by acting on angiotensin II type 2 receptor.

Park MH, Kim HN, Lim JS, Ahn JS, Koh JY.

Mol Brain.

1;6:50.

135

2013.11

Autophagy activation and neuroprotection by progesterone in the G93A-SOD1 transgenic mouse model of amyotrophic lateral sclerosis.

Kim J, Kim TY, Cho KS, Kim HN, Koh JY.

Neurobiol Dis.

59:80-5

134

2013.10

Methallothionein-3 contributes to vascular endothelial growth factor induction in a mouse model of choroidal neovascularization.

Choi JA, Hwang JU, Yoon YH, Koh JY.

Metallomics.

5(10):1387-96.

133

2012.8

Induction of autophagy and cell death by tamoxifen in cultured retinal pigment epithelial and photoreceptor cells.

53(9):5344-53

132

2012.6

Neuropathogenic role of adenylate kinase-1 in Aβ-mediated tau phosphorylation via AMPK and GSK3β.

21(12):2725-37

131

2012.4

Neuroprotection by urokinase plasminogen activator in the hippocampus.

46(1):215-24.

130

2012.3

Alteration of the cerebral zinc pool in a mouse model of Alzheimer disease.

71(3):211-22.

128

2012.1

The neurosteroids, allopregnanolone and progesterone, induce autophagy in cultured astrocytes.

Neurochem Int

60(2):125-33

127

2011.10

Obesity and downregulated hypothalamic leptin receptors in male metallothionein-3-null mice.

Neurobiol Dis

44(1):125-32.

126

2011.9

The role of zinc metallothionein-3 (ZnMT3) in EGF-induced c-Abl activation and actin polymerization in cultured astrocytes.

Lee SJ, Cho KS, Kim HN, Kim HJ, Koh JY.

J Biol Chem.

286(47):40847-56

125

2011.9

Zinc-triggered induction of tissue plasminogen activator by brain-derived neurotrophic factor and metalloproteinases.

J Neurochem

118(5):855-863.

124

2011.8

Dependence of the histofluorescently reactive zinc pool on zinc transporter-3 in the normal brain.

Brain Res.

1418:12-22

123

2011.6

Clioquinol induces autophagy in cultured astrocytes and neurons by acting as a zinc ionophore.

Neurobiol Dis

42(3):242-51

122

2010.10

Roles of zinc and metallothionein-3 in oxidative stress-induced lysosomal dysfunction, cell death, and autophagy in neurons and astrocytes.

Mol Brain

3(1):30.

121

2010.8

Metallothionein-3 regulates lysosomal function in cultured astrocytes under both normal and oxidative conditions.

Lee SJ, Park MH, Kim HJ, Koh JY.

Glia.

58(10):1186-96.

120

2010.4

Chloroquine induces lysosomal dilatation, arrested autophagy and cell death in cultured ARPE-19 cells.

Yoon YH, Cho KS, Hwang JJ, Lee SJ, Choi JA, Koh JY.

Invest Ophthalmol
Vis Sci.

51(11):6030-7

119

2010.4

Apolipoprotein E ablation decreases synaptic vesicular zinc in the brain.

Lee JY, Cho E, Kim TY, Kim DK, Palmiter RD, Volitakis I, Kim JS, Bush AI, Koh JY.

Biometals.

23(6):1085-95

118

2010.4

Zinc(II) ion mediates tamoxifen-induced autophagy and cell death in MCF-7 breast cancer cell line.

Hwang JJ, Kim HN, Kim J, Cho DH, Kim MJ, Kim YS, Kim Y, Park SJ, Koh JY.

Biometals.

23(6):997-1013

117

2010. 2

Endogenous zinc mediates apoptotic programmed cell death in the developing brain.

Cho E, Hwang JJ, Han SH, Chung SJ, Koh JY, Lee JY.

Neurotox Res.

17(2):156-66..

116

2009.10

Age and body weight adjusted warfarin initiation program for ischaemic stroke patients.

Yoo SH, Nah HW, Jo MW, Kang DW, Kim JS, Koh JY, Kwon SU.

Eur J Neurol.

16(10):1100-5

115

2009. 8

Cytosolic labile zinc accumulation in degenerating dopaminergic neurons of mouse brain after MPTP treatment.

Lee JY, Son HJ, Choi JH, Cho E, Kim J, Chung SJ, Hwang O, Koh JY.

Brain Res.

25;1286:208-14.

114

2009. 5

Accumulation of labile zinc in neurons and astrocytes in the spinal cords of G93A SOD-1 transgenic mice.

Kim J, Kim TY, Hwang JJ, Lee JY, Shin JH, Gwag BJ, Koh JY.

Neurobiol Dis.

34(2):221-9.

113

2009. 3

Inflammatory and Hemostatic Biomarkers Associated With Early Recurrent Ischemic Lesions in Acute Ischemic Stroke.

Kang DW, Yoo SH, Chun S, Kwon KY, Kwon SU, Koh JY, Kim JS.

Stroke.

40(5):1653-8.

112

2009. 2

Oxidative injury triggers autophagy in astrocytes: The role of endogenous zinc.

Lee SJ, Cho KS, Koh JY.

Glia.

57(12):1351-61.

111

2009. 3

Ethambutol-induced toxicity is mediated by zinc and lysosomal membrane permeabilization in cultured retinal cells.

Chung H, Yoon YH, Hwang JJ, Cho KS, Koh JY, Kim JG.

Toxicol Appl Pharmacol.

235(2):163-70

110

2008. 10

Essential role for zinc-triggered p75NTR activation in preconditioning neuroprotection.

Lee JY, Kim YJ, Kim TY, Koh JY, Kim YH.

J Neurosci.

28(43):10919-27

109

2008. 7

Inhibitory effect of bevacizumab on the angiogenesis and growth of retinoblastoma.

Lee SY, Kim DK, Cho JH, Koh JY, Yoon YH.

Arch Ophthalmol.

126(7):953-8

108

2008. 6

The involvement of caspase-11 in TPEN-induced apoptosis.

Lee JM, Kim YJ, Ra H, Kang SJ, Han S, Koh JY, Kim YH.

FEBS Lett.

582(13):1871-6

107

2008. 3

Zinc and 4-hydroxy-2-nonenal mediate lysosomal membrane permeabilization induced by H2O2 in cultured hippocampal neurons.

Hwang JJ, Lee SJ, Kim TY, Cho JH, Koh JY.

J Neurosci.

28(12):3114-22

106

2008. 1

Undernutrition as a predictor of poor clinical outcomes in acute ischemic stroke patients.

Yoo SH, Kim JS, Kwon SU, Yun SC, Koh JY, Kang DW.

Arch Neurol.

65(1):39-43

105

2008. 1

Evidence that the ZNT3 protein controls the total amount of elemental zinc in synaptic vesicles.

Linkous DH, Flinn JM, Koh JY, Lanzirotti A, Bertsch PM, Jones BF, Giblin LJ, Frederickson CJ.

J Histochem Cytochem.

56(1):3-6

104

2007. 12

Triamcinolone acetonide-mediated oxidative injury in retinal cell culture: comparison with dexamethasone.

Chung H, Hwang JJ, Koh JY, Kim JG, Yoon YH.

Invest Ophthalmol
Vis Sci.

48(12):5742-9

103

2007. 12

Insulin increases retinal hemorrhage in mild oxygen-induced retinopathy in the rat: inhibition by riluzole.

Yoo MH, Yoon YH, Chung H, Cho KS, Koh JY.

Invest Ophthalmol
Vis Sci.

48(12):5671-6

102

2007. 9

Pyruvate protects against kainate-induced epileptic brain damage in rats.

Kim TY, Yi JS, Chung SJ, Kim DK, Byun HR, Lee JY, Koh JY.

Exp Neurol. 

208(1):159-67

101

2007. 8

Upregulation of tPA/plasminogen proteolytic system in the periphery of amyloid deposits in the Tg2576 mouse model of Alzheimer's disease.

Lee JY, Kweon HS, Cho E, Lee JY, Byun HR, Kim DH, Kim YH, Han PL, Koh JY.

Neurosci Lett.

423(1):82-7

100

2007. 8

Copper activates TrkB in cortical neurons in a metalloproteinase-dependent manner

Hwang JJ, Park MH, Koh JY.

J Neurosci Res.

85(10):2160-6

99

2007. 6

Non-proteolytic neurotrophic effects of tissue plasminogen activator on cultured mouse cerebrocortical neurons.

Lee HY, Hwang IY, Im H, Koh JY, Kim YH.

J Neurochem.

101(5):1236-47.

98

2007. 4

Systemic pyruvate administration markedly reduces infarcts and motor deficits in rat models of transient and permanent focal cerebral ischemia.

Yi JS, Kim TY, Kim DK, Koh JY.

Neurobiol Dis.

26(1):94-104

97

2007. 1

Early recurrent ischemic lesions on diffusion-weighted imaging in symptomatic intracranial atherosclerosis.

Kang DW, Kwon SU, Yoo SH, Kwon KY, Choi CG, Kim SJ, Koh JY, Kim JS.

Arch Neurol.

64(1):50-4

96

2006. 9

A novel phospholipid derivative of indomethacin, DP-155 [mixture of 1-steroyl and 1-palmitoyl-2-{6-[1-(p- chlorobenzoyl)-5-methoxy-2- methyl-3-indolyl acetamido]hexanoyl}- sn-glycero-3-phosophatidyl [corrected] choline], shows superior safety and similar efficacy in reducing brain amyloid beta in an Alzheimer's disease model.

Dvir E, Friedman JE, Lee JY, Koh JY, Younis F, Raz S, Shapiro I, Hoffman A, Dahan A, Rosenberg G, Angel I, Kozak A, Duvdevani R.

J Pharmacol
Exp Ther.

318(3):1248-56

95

 2006. 6

Synaptic release of zinc from brain slices: factors governing release, imaging, and accurate calculation of concentration

Frederickson CJ, Giblin LJ 3rd, Balaji RV, Masalha R, Frederickson CJ, Zeng Y, Lopez EV, Koh JY, Chorin U, Besser L, Hershfinkel M, Li Y, Thompson RB, Krezel A.

 J Neurosci
Methods.

 154(1-2):19-29

94

2005.12

Cytosolic labile zinc: A marker for apoptosis in the developing rat brain

JY Lee, JJ Hwang, MH Park, JY Koh

Eur J Neurosci

23(2):435-42

93

2005.12

Riluzole inhibits VEGF-induced endothelial cell proliferation in vitro and hyperoxida-induced abnormal vessel formation in vivo. 

Yoo MH, Hyun HJ, Koh JY, Yoon YH.

IOVS

46.12:4780-4787

92

2005.11

Progressive neuronal loss and behavioral impairments of transgenic C57BL/6 inbred mice expressing the carboxy terminus of amyloid precursor protein.

Lee KW, Im JY, Song JS, Lee SH, Lee HJ, Ha HY, Koh JY, Gwag BJ, Yang SD, Paik SG, Han PL.

Neurobiol Dis. 

22(1):10-24

91

2005.06

The neurobiology of zinc in health and disease.

Frederickson CJ, Koh JY, Bush AI.

Nat Rev Neurosci. 

6(6):449-62

90

2005.03

Activation of the Trk signaling pathway by extracellular zinc. Role of metalloproteinases.

Hwang JJ, Park MH, Choi SY, Koh JY.

J Biol Chem. 

280(12):11995-2001

89

2004.11

The lipophilic metal chelator DP-109 reduces amyloid pathology in brains of human beta-amyloid precursor protein transgenic mice.

Lee JY, Friedman JE, Angel I, Kozak A, Koh JY.

Neurobiol Aging. 

25(10):1315-21

88

2004.10

Infarct reduction in rats following intraventricular administration of either tissue plasminogen activator (tPA) or its non-protease mutant S478A-tPA.

Yi JS, Kim YH, Koh JY.

Exp Neurol. 

189(2):354-60

87

2004.05

Danthron inhibits the neurotoxicity induced by various compounds causing oxidative damages including beta-amyloid (25-35) in primary cortical cultures.

Kwon YS, Koh JY, Song DK, Kim HC, Kwon MS, Choi YS, Wie MB.

Biol Pharm Bull. 

27(5):723-6

86

2004.05

Protection by pyruvate of rat retinal cells against zinc toxicity in vitro, and pressure-induced ischemia in vivo.

Yoo MH, Lee JY, Lee SE, Koh JY, Yoon YH.

Invest Ophthalmol
Vis Sci.
 

45(5):1523-30

85

2004.03

Neuronal zinc exchange with the blood vessel wall promotes cerebral amyloid angiopathy in an animal model of Alzheimer's disease.

Friedlich AL, Lee JY, van Groen T, Cherny RA, Volitakis I, Cole TB, Palmiter RD, Koh JY, Bush AI.

J Neurosci. 

24(13):3453-9

84

2004.03

Estrogen decreases zinc transporter 3 expression and synaptic vesicle zinc levels in mouse brain.

Lee JY, Kim JH, Hong SH, Lee JY, Cherny RA, Bush AI, Palmiter RD, Koh JY.

J Biol Chem. 

279(10):8602-7

83

2004.02

Induction of pro-apoptotic calsenilin/DREAM/KChIP3 in Alzheimer's disease and cultured neurons after amyloid-beta exposure.

Jo DG, Lee JY, Hong YM, Song S, Mook-Jung I, Koh JY, Jung YK.

J Neurochem. 

88(3):604-11

82

2004.02

NR2A induction and NMDA receptor-dependent neuronal death by neurotrophin-4/5 in cortical cell culture.

Choi SY, Hwang JJ, Koh JY.

J Neurochem. 

88(3):708-16

81

2003.11

Zinc released from metallothionein-iii may contribute to hippocampal CA1 and thalamic neuronal death following acute brain injury.

Lee JY, Kim JH, Palmiter RD, Koh JY.

Exp Neurol. 

184(1):337-47

80

2003.10

TrkB mediates BDNF-induced potentiation of neuronal necrosis in cortical culture.

Kim HJ, Hwang JJ, Behrens MM, Snider BJ, Choi DW, Koh JY.

Neurobiol Dis. 

14(1):110-9

79

2003.09

Essential role of E2-25K/Hip-2 in mediating amyloid-beta neurotoxicity.

Song S, Kim SY, Hong YM, Jo DG, Lee JY, Shim SM, Chung CW, Seo SJ, Yoo YJ, Koh JY, Lee MC, Yates AJ, Ichijo H, Jung YK.

Mol Cell. 

12(3):553-63

78

2003.09

Pyruvate inhibits zinc-mediated pancreatic islet cell death and diabetes.

Chang I, Cho N, Koh JY, Lee MS.

Diabetologia. 

46(9):1220-7

77

2003.08

Co-induction of p75(NTR) and the associated death executor NADE in degenerating hippocampal neurons after kainate-induced seizures in the rat.

Yi JS, Lee SK, Sato TA, Koh JY.

Neurosci Lett. 

347(2):126-30

76

2003.07

Design and biological evaluation of novel antioxidants containing N-t-Butyl-N-hydroxylaminophenyl moieties.

Kim KM, Kim KH, Kang TC, Kim WY, Lee M, Jung HJ, Hwang IK, Ko SB, Koh JY, Won MH, Oh E, Shin I.

Bioorg Med
Chem Lett.
 

13(14):2273-5

75

2003.05

Down-regulation of ARC contributes to vulnerability of hippocampal neurons to ischemia/hypoxia.

Hong YM, Jo DG, Lee JY, Chang JW, Nam JH, Noh JY, Koh JY, Jung YK.

FEBS Lett. 

543(1-3):170-3

74

2002.12

Depletion of intracellular zinc from neurons by use of an extracellular chelator in vivo and in vitro.

Frederickson CJ, Suh SW, Koh JY, Cha YK, Thompson RB, LaBuda CJ, Balaji RV, Cuajungco MP.

J Histochem Cytochem. 

50(12):1659-62

73

2002.11

Augmentation by zinc of NMDA receptor-mediated synaptic responses in CA1 of rat hippocampal slices: mediation by Src family tyrosine kinases.

Kim TY, Hwang JJ, Yun SH, Jung MW, Koh JY.

Synapse

46(2):49-56

72

2002.10

The role of NADPH oxidase and neuronal nitric oxide synthase in zinc-induced poly(ADP-ribose) polymerase activation and cell death in cortical culture.

Kim YH, Koh JY.

Exp Neurol. 

177(2):407-18

71

2002.08

The role of NADPH oxidase, neuronal nitric oxide synthase and poly(ADP ribose) polymerase in oxidative neuronal death induced in cortical cultures by brain-derived neurotrophic factor and neurotrophin-4/5.

Hwang JJ, Choi SY, Koh JY.

J Neurochem. 

82(4):894-902

70

2002.05

Contribution by synaptic zinc to the gender-disparate plaque formation in human Swedish mutant APP transgenic mice.

Lee JY, Cole TB, Palmiter RD, Suh SW, Koh JY.

Proc Natl Acad
Sci U S A.
 

99(11):7705-10

69

2001

BAPTA/AM, an intracellular calcium chelator, induces delayed necrosis by lipoxygenase-mediated free radicals in mouse cortical cultures.

Wie MB, Koh JY, Won MH, Lee JC, Shin TK, Moon CJ, Ha HJ, Park SM, Kim HC.

Prog Neuropsychopharmacol Biol Psychiatry. 

25(8):1641-59

68

2001.10

Protection by pyruvate against transient forebrain ischemia in rats.

Lee JY, Kim YH, Koh JY.

J Neurosci. 

21(20):RC171

67

2001.02

Depletion of intracellular zinc and copper with TPEN results in apoptosis of cultured human retinal pigment epithelial cells.

Hyun HJ, Sohn JH, Ha DW, Ahn YH, Koh JY, Yoon YH.

Invest Ophthalmol Vis Sci. 

42(2):460-5

66

2001.01

Zinc and disease of the brain.

Koh JY.

Mol Neurobiol. 

24(1-3):99-106

65

2000.12

Co-induction of p75NTR and p75NTR-associated death executor (NADE) in neurons after zinc exposure in cortical culture or transient ischemia in the rat

Jeong Ae Park, Joo-Yong Lee, Taka-Aki Sato, and Jae-Young Koh

J Neurosci

20:9096-9103

64

2000.12

Induction and activation by zinc of NADPH oxidase in cultured cortical neurons and astrocytes.

Noh KM, Koh JY.

J Neurosci. 

20(23):RC111

63

2000.10

Zn(2+): a novel ionic mediator of neural injury in brain disease.

Weiss JH, Sensi SL, Koh JY.

Trends Pharmacol Sci. 

21(10):395-401

62

2000.09

Protein synthesis-dependent but Bcl-2-independent cytochrome C release in zinc depletion-induced neuronal apoptosis.

Ahn YH, Koh JY, Hong SH.

J Neurosci Res. 

61(5):508-14

61

2000.08

A novel neuroprotective mechanism of riluzole: direct inhibition of protein kinase C.

Noh KM, Hwang JY, Shin HC, Koh JY.

Neurobiol Dis. 

7(4):375-83

60

2000.07

Epidermal growth factor induces oxidative neuronal injury in cortical culture.

Cha YK, Kim YH, Ahn YH, Koh JY.

J Neurochem. 

75(1):298-303

59

2000.06

Depletion of intracellular zinc induces macromolecule synthesis- and caspase-dependent apoptosis of cultured retinal cells.

Hyun HJ, Sohn J, Ahn YH, Shin HC, Koh JY, Yoon YH.

Brain Res. 

869(1-2):39-48

58

2000.06

Accumulation of zinc in degenerating hippocampal neurons of ZnT3-null mice after seizures: evidence against synaptic vesicle origin.

Lee JY, Cole TB, Palmiter RD, Koh JY.

J Neurosci. 

20(11):RC79

57

2000.03

Zinc as a paracrine effector in pancreatic islet cell death.

Kim BJ, Kim YH, Kim S, Kim JW, Koh JY, Oh SH, Lee MK, Kim KW, Lee MS.

Diabetes. 

49(3):367-72

56

2000.02

Anti-oxidative neuroprotection by estrogens in mouse cortical cultures.

Young Hee Bae and Jae-Young Koh

J. Kor. Med.Sci

15(3), 327-336

55

2000.02

Induction by synaptic zinc of heat shock protein-70 in hippocampus after kainate seizures.

Lee JY, Park J, Kim YH, Kim DH, Kim CG, Koh JY.

Exp Neurol. 

161(2):433-41

54

2000.01

Ethambutol-induced vacuolar changes and neuronal loss in rat retinal cell culture: mediation by endogenous zinc.

Yoon YH, Jung KH, Sadun AA, Shin HC, Koh JY.

Toxicol Appl Pharmacol. 

162(2):107-14

53

1999.11

Protective effects of asiaticoside derivatives against beta-amyloid neurotoxicity.

Mook-Jung I, Shin JE, Yun SH, Huh K, Koh JY, Park HK, Jew SS, Jung MW.

J Neurosci Res. 

58(3):417-25

52

1999.10

Prevention of neuronal apoptosis by phorbol ester-induced activation of protein kinase C: blockade of p38 mitogen-activated protein kinase.

Behrens MM, Strasser U, Koh JY, Gwag BJ, Choi DW.

Neuroscience

94(3):917-27

51

1999.09

N-Methyl-D-aspartate receptor blockade induces neuronal apoptosis in cortical culture.

Hwang JY, Kim YH, Ahn YH, Wie MB, Koh JY.

Exp Neurol. 

159(1):124-30

50

1999.08

Induction of an immediate early gene egr-1 by zinc through extracellular signal-regulated kinase activation in cortical culture: its role in zinc-induced neuronal death.

Park JA, Koh JY.

J Neurochem. 

73(2):450-6

49

1999.07

Presenilin 1 mediates protein kinase C dependent alpha-secretase derived amyloid precursor protein secretion and mitogen-activated protein kinase activation in presenilin 1 transfected human embryonic kidney 293 cell.

Shin JE, Koh JY, Mook-Jung I.

Neurosci Lett. 

269(2):99-102

48

1999.06

Calcium ionophores can induce either apoptosis or necrosis in cultured cortical neurons.

Gwag BJ, Canzoniero LM, Sensi SL, Demaro JA, Koh JY, Goldberg MP, Jacquin M, Choi DW.

Neuroscience

90(4):1339-48

47

1999.06

Insulin-induced oxidative neuronal injury in cortical culture: mediation by induced N-methyl-D-aspartate receptors.

Noh KM, Lee JC, Ahn YH, Hong SH, Koh JY.

IUBMB Life. 

48(3):263-9

46

1999.04

Nonproteolytic neuroprotection by human recombinant tissue plasminogen activator.

Kim YH, Park JH, Hong SH, Koh JY.

Science

284(5414):647-50

45

1999.04

Mediation by membrane protein kinase C of zinc-induced oxidative neuronal injury in mouse cortical cultures.

Noh KM, Kim YH, Koh JY.

J Neurochem. 

72(4):1609-16

44

1999.03

Vertebrobasilar artery territory infarction as an initial manifestation of systemic lupus erythematosus.

Kwon SU, Koh JY, Kim JS.

Clin Neurol Neurosurg. 

101(1):62-7

43

1999.03

High vulnerability of GABA-immunoreactive neurons to kainate in rat retinal cultures: correlation with the kainate-stimulated cobalt uptake.

Yoon YH, Jeong KH, Shim MJ, Koh JY.

Brain Res. 

823(1-2):33-41

42

1999.03

Zinc-induced cortical neuronal death with features of apoptosis and necrosis: mediation by free radicals.

Kim YH, Kim EY, Gwag BJ, Sohn S, Koh JY.

Neuroscience

89(1):175-82

41

1999.02

Antioxidative and proapoptotic effects of riluzole on cultured cortical neurons.

Koh JY, Kim DK, Hwang JY, Kim YH, Seo JH.

J Neurochem. 

72(2):716-23

40

1999.02

beta-amyloid-induced changes of sensory transmission in the SI cortex of aneshesized rats

 

 

 

39

1999.01

Histochemically reactive zinc in plaques of the Swedish mutant beta-amyloid precursor protein transgenic mice.

Lee JY, Mook-Jung I, Koh JY.

J Neurosci. 

19(11):RC10

38

1999.01

Zn2+ entry produces oxidative neuronal necrosis in cortical cell cultures.

Kim EY, Koh JY, Kim YH, Sohn S, Joe E, Gwag BJ.

Eur J Neurosci. 

11(1):327-34

37

1998.11

Depletion of intracellular zinc induces protein synthesis-dependent neuronal apoptosis in mouse cortical culture.

Ahn YH, Kim YH, Hong SH, Koh JY.

Exp Neurol. 

154(1):47-56

36

1998.10

Medial medullary infarction with restricted sensory symptom.

Kim JS, Koh JY, Lee JH.

Eur Neurol. 

39(3):174-7

35

1998.03

Zinc and brain injury.

Choi DW, Koh JY.

Annu Rev Neurosci. 

21:347-75

34

1997.12

Measurement of intracellular free zinc in living cortical neurons: routes of entry.

Sensi SL, Canzoniero LM, Yu SP, Ying HS, Koh JY, Kerchner GA, Choi DW.

J Neurosci. 

17(24):9554-64

33

1997.03

Slowly triggered excitotoxicity occurs by necrosis in cortical cultures.

Gwag BJ, Koh JY, DeMaro JA, Ying HS, Jacquin M, Choi DW.

Neuroscience

77(2):393-401

32

1996.05

The role of zinc in selective neuronal death after transient global cerebral ischemia.

Koh JY, Suh SW, Gwag BJ, He YY, Hsu CY, Choi DW.

Science

272(5264):1013-6

31

1996.06

NADPH diaphorase-containing striatal or cortical neurons are resistant to apoptosis.

Behrens MI, Koh JY, Muller MC, Choi DW.

Neurobiol Dis. 

3(1):72-5

30

1995.12

BDNF or IGF-I potentiates free radical-mediated injury in cortical cell cultures.

Gwag BJ, Koh JY, Chen MM, Dugan LL, Behrens MM, Lobner D, Choi DW.

Neuroreport. 

7(1):93-6

29

1995.10

Staurosporine-induced neuronal apoptosis.

Koh JY, Wie MB, Gwag BJ, Sensi SL, Canzoniero LM, Demaro J, Csernansky C, Choi DW.

Exp Neurol. 

135(2):153-9

28

1995.10

Blockade of glutamate receptors unmasks neuronal apoptosis after oxygen-glucose deprivation in vitro.

Gwag BJ, Lobner D, Koh JY, Wie MB, Choi DW.

Neuroscience

68(3):615-9

27

1995.04

Potentiated necrosis of cultured cortical neurons by neurotrophins.

Koh JY, Gwag BJ, Lobner D, Choi DW.

Science

268(5210):573-5

26

1995.02

3-Nitropropionic acid induces apoptosis in cultured striatal and cortical neurons.

Behrens MI, Koh J, Canzoniero LM, Sensi SL, Csernansky CA, Choi DW.

Neuroreport. 

6(3):545-8

25

1994.06

Zinc toxicity on cultured cortical neurons: involvement of N-methyl-D-aspartate receptors.

Koh JY, Choi DW.

Neuroscience. 

60(4):1049-57

24

1993.01

AMPA receptor activation potentiates zinc neurotoxicity.

Weiss JH, Hartley DM, Koh JY, Choi DW.

Neuron. 

10(1):43-9

23

1992.08

Programmed cell death: its possible contribution to neurotoxicity mediated by calcium channel antagonists.

Koh JY, Cotman CW.

Brain Res. 

587(2):233-40

22

1991.12

Beta-amyloid increases neuronal susceptibility to injury by glucose deprivation.

Copani A, Koh JY, Cotman CW.

Neuroreport. 

2(12):763-5

21

1991.11

Activation of the metabotropic glutamate receptor attenuates N-methyl-D-aspartate neurotoxicity in cortical cultures.

Koh JY, Palmer E, Cotman CW.

Proc Natl Acad Sci U S A. 

88(21):9431-5

20

1991.10

A metabotropic glutamate receptor agonist does not mediate neuronal degeneration in cortical culture.

Koh JY, Palmer E, Lin A, Cotman CW.

Brain Res. 

561(2):338-43

19

1991.05

Selective blockade of non-NMDA receptors does not block rapidly triggered glutamate-induced neuronal death.

Koh JY, Choi DW.

Brain Res. 

548(1-2):318-21

18

1991.01

Increased excitotoxic vulnerability of cortical cultures with reduced levels of glutathione.

Bridges RJ, Koh JY, Hatalski CG, Cotman CW.

Eur J Pharmacol. 

192(1):199-200

17

1990.11

Beta-amyloid protein increases the vulnerability of cultured cortical neurons to excitotoxic damage.

Koh JY, Yang LL, Cotman CW.

Brain Res. 

533(2):315-20

16

1990.08

Cortical neurons containing somatostatin- or parvalbumin-like immunoreactivity are atypically vulnerable to excitotoxic injury in vitro.

Weiss JH, Koh J, Baimbridge KG, Choi DW.

Neurology. 

40(8):1288-92

15

1990.03

The calcium channel blocker nifedipine attenuates slow excitatory amino acid neurotoxicity.

Weiss JH, Hartley DM, Koh J, Choi DW.

Science

247(4949 Pt 1):1474-7

14

1990.02

Non-NMDA receptor-mediated neurotoxicity in cortical culture.

Koh JY, Goldberg MP, Hartley DM, Choi DW.

J Neurosci. 

10(2):693-705

13

1989.09

Neurotoxicity of beta-N-methylamino-L-alanine (BMAA) and beta-N-oxalylamino-L-alanine (BOAA) on cultured cortical neurons.

Weiss JH, Koh JY, Choi DW.

Brain Res. 

497(1):64-71

12

1989.03

Zinc and LTP.

Weiss JH, Koh JY, Christine CW, Choi DW.

Nature

338(6212):212

11

1988.06

Zinc alters excitatory amino acid neurotoxicity on cortical neurons.

Koh JY, Choi DW.

J Neurosci. 

8(6):2164-71

10

1988.06

Vulnerability of cultured cortical neurons to damage by excitotoxins: differential susceptibility of neurons containing NADPH-diaphorase.

Koh JY, Choi DW.

J Neurosci. 

8(6):2153-63

9

1988.04

Cultured striatal neurons containing NADPH-diaphorase or acetylcholinesterase are selectively resistant to injury by NMDA receptor agonists.

Koh JY, Choi DW.

Brain Res.

446(2):374-8

8

1988.01

Zinc neurotoxicity in cortical cell culture.

Choi DW, Yokoyama M, Koh J.

Neuroscience. 

24(1):67-79

7

1988.01

Pharmacology of glutamate neurotoxicity in cortical cell culture: attenuation by NMDA antagonists.

Choi DW, Koh JY, Peters S.

J Neurosci. 

8(1):185-96

6

1987.12

L-homocysteate is a potent neurotoxin on cultured cortical neurons.

Kim JP, Koh JY, Choi DW.

Brain Res. 

437(1):103-10

5

1987.05

Quantitative determination of glutamate mediated cortical neuronal injury in cell culture by lactate dehydrogenase efflux assay.

Koh JY, Choi DW.

J Neurosci Methods. 

20(1):83-90

4

1987.02

Zinc selectively blocks the action of N-methyl-D-aspartate on cortical neurons.

Peters S, Koh J, Choi DW.

Science

236(4801):589-93

3

1987.02

Effect of anticonvulsant drugs on glutamate neurotoxicity in cortical cell culture.

Koh JY, Choi DW.

Neurology

37(2):319-22

2

1986.11

Brief exposure to zinc is toxic to cortical neurons.

Yokoyama M, Koh J, Choi DW.

Neurosci Lett. 

71(3):351-5

1

1986.10

Neurons containing NADPH-diaphorase are selectively resistant to quinolinate toxicity.

Koh JY, Peters S, Choi DW.

Science

234(4772):73-6